Corticospinal tract transduction: a comparison of seven adeno-associated viral vector serotypes and a non-integrating lentiviral vector

@inproceedings{Hutson2012CorticospinalTT,
  title={Corticospinal tract transduction: a comparison of seven adeno-associated viral vector serotypes and a non-integrating lentiviral vector},
  author={Thomas Haynes Hutson and Joost Verhaagen and Rafael Joaqu{\'i}n Y{\'a}{\~n}ez-Mu{\~n}oz and Lawrence D. F. Moon},
  booktitle={Gene Therapy},
  year={2012}
}
The corticospinal tract (CST) is extensively used as a model system for assessing potential therapies to enhance neuronal regeneration and functional recovery following spinal cord injury (SCI). However, efficient transduction of the CST is challenging and remains to be optimised. Recombinant adeno-associated viral (AAV) vectors and integration-deficient lentiviral vectors are promising therapeutic delivery systems for gene therapy to the central nervous system (CNS). In the present study the… CONTINUE READING

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