Corticospinal Circuits from the Sensory and Motor Cortices Differentially Regulate Skilled Movements through Distinct Spinal Interneurons.

@article{Ueno2018CorticospinalCF,
  title={Corticospinal Circuits from the Sensory and Motor Cortices Differentially Regulate Skilled Movements through Distinct Spinal Interneurons.},
  author={M. Ueno and Yuka Nakamura and J. Li and Zirong Gu and Jesse Niehaus and Mari Maezawa and Steven A Crone and M. Goulding and M. Baccei and Yutaka Yoshida},
  journal={Cell reports},
  year={2018},
  volume={23 5},
  pages={
          1286-1300.e7
        }
}
Little is known about the organizational and functional connectivity of the corticospinal (CS) circuits that are essential for voluntary movement. Here, we map the connectivity between CS neurons in the forelimb motor and sensory cortices and various spinal interneurons, demonstrating that distinct CS-interneuron circuits control specific aspects of skilled movements. CS fibers originating in the mouse motor cortex directly synapse onto premotor interneurons, including those expressing Chx10… Expand
Mouse corticospinal system comprises different functional neuronal ensembles depending on their hodology
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