Corticolimbic metabolic dysregulation in euthymic older adults with bipolar disorder.

@article{Brooks2009CorticolimbicMD,
  title={Corticolimbic metabolic dysregulation in euthymic older adults with bipolar disorder.},
  author={John O Brooks and Jennifer C Hoblyn and Stephanie A Woodard and Allyson C. Rosen and Terence A. Ketter},
  journal={Journal of psychiatric research},
  year={2009},
  volume={43 5},
  pages={497-502}
}
The corticolimbic dysregulation hypothesis of bipolar disorder suggests that depressive symptoms are related to dysregulation of components of an anterior paralimbic network (anterior cingulate, anterior temporal cortex, dorsolateral prefrontal cortex, parahippocampal gyrus, and amygdala) with excessive anterior limbic activity accompanied by diminished prefrontal activity. In younger patients, such abnormalities tend to resolve with remission of depression, but it remains to be established… CONTINUE READING

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