Corticobasal degeneration with focal, massive tau accumulation in the subcortical white matter astrocytes

@article{Sakai2006CorticobasalDW,
  title={Corticobasal degeneration with focal, massive tau accumulation in the subcortical white matter astrocytes},
  author={Kenji Sakai and Yue-Shan Piao and Koki Kikugawa and Shinji Ohara and Masato Hasegawa and Hiroki Takano and Masayuki Fukase and Masatoyo Nishizawa and Akiyoshi Kakita and Hitoshi Takahashi},
  journal={Acta Neuropathologica},
  year={2006},
  volume={112},
  pages={341-348}
}
We report two sporadic cases of tauopathy with unusual neuropathological features. The ages of the patients at death were 86 and 74 years, and the disease durations were 4 and 3 years, respectively. The former patient showed progressive dementia and amyotrophy (autopsy revealed that severe cervical spondylosis was responsible for the amyotrophy), and the latter showed progressive parkinsonism and dementia. The essential brain pathologies were similar to each other; although ballooned neurons… CONTINUE READING

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