Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy.

  title={Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy.},
  author={Emilio Di Maria and Massimo Tabaton and Tiziana Vigo and Giovanni Abbruzzese and Emilia Bellone and Cristina Donati and Emma Frasson and Roberta Marchese and Pasquale Montagna and David Gonz{\'a}lez Mu{\~n}oz and Peter P. Pramstaller and Gianluigi Zanusso and Franco Ajmar and Paola Mandich},
  journal={Annals of neurology},
  volume={47 3},
Corticobasal degeneration is a sporadic form of tauopathy, involving the cerebral cortex and extrapyramidal motor system. A series of affected subjects was genotyped for a set of genetic markers along the tau protein gene. A specific haplotype is significantly overrepresented in patients versus controls. This haplotype is the same already reported in association with progressive supranuclear palsy. These data show that corticobasal degeneration and progressive supranuclear palsy, in addition to… CONTINUE READING


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