Cortical surface area and IQ in very-low-birth-weight (VLBW) young adults

  title={Cortical surface area and IQ in very-low-birth-weight (VLBW) young adults},
  author={Jon Skranes and Gro C. Christensen L{\o}haugen and Marit Martinussen and Asta Kristine H{\aa}berg and Ann-Mari Brubakk and Anders M. Dale},
Brain volumes and cognitive function in very-low-birth-weight (VLBW) young adults.
Trajectories of brain development in school-age children born preterm with very low birth weight
Divergent or “catch-up” growth in terms of cortical thickness, surface area, and volumes of subcortical gray matter structures and corpus callosum in children born preterm/VLBW and did not find group × time interactions.
Extremely preterm children exhibit altered cortical thickness in language areas
To characterize possible language network cortical thickness effects, 15 EPT children and 15 TC underwent standardized assessments of language and structural magnetic resonance imaging at 4 to 6 years of age, and only ICV-normalized results were significantly related to language scores, with right temporal cortical thickness being positively correlated with performance.
Born Too Early and Too Small: Higher Order Cognitive Function and Brain at Risk at Ages 8–16
The data indicate that facets of executive function and IQ are the most affected in VP-VLBW children likely due to altered higher order cortical areas and underlying WM.
Preterm birth and structural brain alterations in early adulthood


Cerebral cortex thickness in 15-year-old adolescents with low birth weight measured by an automated MRI-based method.
Observed reorganization of the developing brain offers a unique opportunity to investigate any relationship between changes in cortical anatomy and cognitive and social impairments, and the increase in psychiatric disorders that have been found in VLBW children and adolescents.
Clinical findings and white matter abnormalities seen on diffusion tensor imaging in adolescents with very low birth weight.
DTI was able to detect differences in FA between VLBW adolescents and controls in several white matter areas at risk of periventricular leucomalacia in V LBW newborns, indicating that perinatal injury of white matter tracts persist with clinical significance in adolescence.
Grey and white matter distribution in very preterm adolescents mediates neurodevelopmental outcome.
Investigation of voxel-based morphometry demonstrated that anatomical brain changes may contribute to specific cognitive deficits associated with VPT birth and could be used in the identification of those individuals who may be at increased risk for cognitive impairment.
Abnormal Cortical Development after Premature Birth Shown by Altered Allometric Scaling of Brain Growth
Human brain growth obeys an allometric scaling relation that is disrupted by preterm birth in a dose-dependent, sexually dimorphic fashion that directly parallels the incidence of neurodevelopmental impairments in preterm infants.
Abnormal Cerebral Structure Is Present at Term in Premature Infants
This MRI study of prematurely born infants further defines the nature of quantitative cerebral structural abnormalities present as early as term equivalent and is related most significantly to the degree of immaturity at birth and to concomitant WM injury.
Quantitative magnetic resonance imaging of brain development in premature and mature newborns
The application of 3D MRI and tissue segmentation to the study of human infant brain from 29 to 41 weeks of postconceptional age has provided new insights into cerebral cortical development and myelination and has for the first time provided means of quantitative assessment in vivo of early human brain development.