Cortical spreading depression protects against subsequent focal cerebral ischemia in rats.

@article{Matsushima1996CorticalSD,
  title={Cortical spreading depression protects against subsequent focal cerebral ischemia in rats.},
  author={Kazuaki Matsushima and Matthew J Hogan and Antoine M. Hakim},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={1996},
  volume={16 2},
  pages={221-6}
}
The possibility that cortical spreading depression (CSD) may have neuroprotective action during subsequent focal cerebral ischemia was examined in rats. Three days before the imposition of focal cerebral ischemia CSDs were elicited by applying potassium chloride (KC1) for 2 h through a microdialysis probe implanted in the occipital cortex. Control animals were handled identically except that saline was infused instead of KC1. Focal ischemia was produced by the intraluminal suture method and… CONTINUE READING
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