Cortical spreading depression induces the expression of iNOS, HIF-1alpha, and LDH-A.

@article{Viggiano2008CorticalSD,
  title={Cortical spreading depression induces the expression of iNOS, HIF-1alpha, and LDH-A.},
  author={E Viggiano and Dardo E. Ferrara and Gaia Izzo and Andrea Viggiano and Sergio Minucci and Marcellino Monda and Bruno De Luca},
  journal={Neuroscience},
  year={2008},
  volume={153 1},
  pages={182-8}
}
The mechanisms of tolerance to subsequent episodes of ischemia induced by cortical spreading depression (CSD) are not clear. The effects of CSD on the expression of inducible nitric oxide synthase (iNOS), hypoxia inducible factor-1alpha (HIF-1alpha), and lactate dehydrogenase-A (LDH-A) were evaluated in the present experiment. Unilateral CSD was induced in Sprague-Dawley rats by application of KCl on the right cortex and the mRNA levels of iNOS, HIF-1alpha, and LDH-A were evaluated at 15 min, 2… CONTINUE READING

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