Cortical potentials evoked by tooth pulp stimulation differentiate between the analgesic and sedative effects of morphine in awake rats.

@article{Danneman1994CorticalPE,
  title={Cortical potentials evoked by tooth pulp stimulation differentiate between the analgesic and sedative effects of morphine in awake rats.},
  author={Peggy J. Danneman},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1994},
  volume={269 3},
  pages={
          1100-6
        }
}
This study was undertaken to determine whether the cortical potential (CEP) evoked by noxious electrical stimulation of the incisor tooth pulp can be used to measure analgesia in the presence of sedation in the awake rat. Changes in the CEP produced by morphine (5, 10 and 20 mg/kg s.c.), an opioid analgesic with sedative effects, were compared with those produced by droperidol (1.25 mg/kg s.c.), a neuroleptic agent with no analgesic activity. Both drugs had similar small effects on CEP latency… CONTINUE READING