Cortical plasticity in Alzheimer's disease in humans and rodents.

  title={Cortical plasticity in Alzheimer's disease in humans and rodents.},
  author={Fortunato Battaglia and Hoau-Yan Wang and Marie Felice Ghilardi and Eleonora Gashi and A. Quartarone and Eitan Friedman and Ralph A. Nixon},
  journal={Biological psychiatry},
  volume={62 12},
BACKGROUND The aim of this study was to determine whether neocortical long-term potentiation (LTP) is deficient in patients with Alzheimer's disease (AD) and in amyloid precursor protein (APP)/presenilin-1 (PS1) mice, an AD animal model. We then ascertained whether this deficit might be paralleled by functional abnormalities of N-methyl-D-aspartate (NMDAR) glutamate receptors. METHODS We studied neocortical LTP-like plasticity in 10 patients with mild-to-moderate AD and 10 age-matched normal… CONTINUE READING
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