Cortical plasticity: from synapses to maps.

@article{Buonomano1998CorticalPF,
  title={Cortical plasticity: from synapses to maps.},
  author={Dean V. Buonomano and Michael Merzenich},
  journal={Annual review of neuroscience},
  year={1998},
  volume={21},
  pages={
          149-86
        }
}
It has been clear for almost two decades that cortical representations in adult animals are not fixed entities, but rather, are dynamic and are continuously modified by experience. The cortex can preferentially allocate area to represent the particular peripheral input sources that are proportionally most used. Alterations in cortical representations appear to underlie learning tasks dependent on the use of the behaviorally important peripheral inputs that they represent. The rules governing… 

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References

SHOWING 1-10 OF 253 REFERENCES
Plasticity in the organization of adult cerebral cortical maps: a computer simulation based on neuronal group selection
TLDR
A computer model based on the process of neuronal group selection has been constructed that accounts for reported results on map plasticity in somatosensory cortex and provides several insights into the mechanisms of such changes, as well as a series of predictions about cortical behavior for further experimental test.
GABAergic neurons and their role in cortical plasticity in primates.
  • E. Jones
  • Biology, Psychology
    Cerebral cortex
  • 1993
TLDR
There is a potential mechanism for the plasticity of representational maps that is demonstrable in somatic sensory, motor, auditory, and visual cortex as well as in primate neocortex.
Postsynaptic control of plasticity in developing somatosensory cortex
TLDR
It is reported here that the selective disruption of postsynaptic activation in rat S1 by application of a glutamate receptor antagonist inhibits rearrangements in the somatotopic patterning of thalamocorticalafferents induced by manipulations of the sensory periphery during the critical period.
Experience-dependent modification of synaptic plasticity in visual cortex
TLDR
In visual cortex of light-deprived rats that LTP is enhanced and LTD diminished over a range of stimulation frequencies, and that these effects can be reversed by as little as two days of light exposure, support the idea that a variable synaptic-modification threshold allows synaptic weights in neural networks to achieve a stable equilibrium.
From biophysics to models of network function.
  • E. Marder
  • Biology
    Annual review of neuroscience
  • 1998
TLDR
This review presents some recent models that illustrate that short-term synaptic plasticity mechanisms such as facilitation and depression can have important implications for network function.
Associative synaptic plasticity in hippocampal CA1 neurons is not sensitive to unpaired presynaptic activity.
TLDR
The results indicate that the presence of unpaired presynaptic pulses does not alter the induction of synaptic plasticity, suggesting that plasticity of the Schaffer collateral-CA1 synapse is primarily conjunctive rather than correlative.
A critical period for long-term potentiation at thalamocortical synapses
TLDR
Theperiod during which LTP can be induced matches closely the critical period during which the barrels can be modified by sensory perturbations, providing compelling evidence that LTP is important for the development of cortical circuitry.
NMDA receptors and plasticity in adult primate somatosensory cortex
TLDR
Much of the cortical “recovery” that typically follows peripheral nerve injury in adult monkeys is apparently dependent on NMDA receptors and may well be due to Hebbian‐like changes in synaptic strength.
Cortical Map Reorganization as a Competitive Process
TLDR
This model exhibits spontaneous map reorganization in response to a cortical lesion, going through a two-phase reorganization process and makes a testable prediction that can be used to experimentally support or refute part of the competitive distribution hypothesis, and may lead to practically useful computational models of recovery following stroke.
Remodelling of hand representation in adult cortex determined by timing of tactile stimulation
TLDR
It is shown, using adult owl monkeys trained to respond to specific stimulus sequence events, that serial application of stimuli to the fingers results in changes to the neuronal response specificity and maps of the hand surfaces in the true primary somatosensory cortical field.
...
...