Cortical parvalbumin GABAergic deficits with α7 nicotinic acetylcholine receptor deletion: implications for schizophrenia.

@article{Lin2014CorticalPG,
  title={Cortical parvalbumin GABAergic deficits with α7 nicotinic acetylcholine receptor deletion: implications for schizophrenia.},
  author={Hong Lin and Fu-Chun Hsu and Bailey H Baumann and Douglas A. Coulter and Stewart A. Anderson and David R Lynch},
  journal={Molecular and cellular neurosciences},
  year={2014},
  volume={61},
  pages={163-75}
}
Dysfunction of cortical parvalbumin (PV)-containing GABAergic interneurons has been implicated in cognitive deficits of schizophrenia. In humans microdeletion of the CHRNA7 (α7 nicotinic acetylcholine receptor, nAChR) gene is associated with cortical dysfunction in a broad spectrum of neurodevelopmental and neuropsychiatric disorders including schizophrenia while in mice similar deletion causes analogous abnormalities including impaired attention, working-memory and learning. However, the… CONTINUE READING
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