Cortical neurons immunoreactive with antisera against neuropeptide Y are altered in Alzheimer's-type dementia.

@article{ChanPalay1985CorticalNI,
  title={Cortical neurons immunoreactive with antisera against neuropeptide Y are altered in Alzheimer's-type dementia.},
  author={Victoria Chan-Palay and W. Lang and Y. S. Allen and U Haesler and Julia M. Polak},
  journal={The Journal of comparative neurology},
  year={1985},
  volume={238 4},
  pages={
          390-400
        }
}
Neurons identified by their immunoreactivity with antisera against neuropeptide Y (NPY) were studied in three selected areas of the cerebral cortex in brains from controls and in senile dementia of the Alzheimer type (ATD). Changes were more profound in temporal cortex than in parietal cortex, and more severe in parietal cortex than in frontal cortex, paralleling the severity of neuritic plaque formation and incidence of neurofibrillary tangles in these regions. NPY-i neurons became distorted… CONTINUE READING

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Neuropeptide Y and its role in CNS disease and repair

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  • 2012
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