Cortical neuronal migration mutants suggest separate but intersecting pathways.

  title={Cortical neuronal migration mutants suggest separate but intersecting pathways.},
  author={Stephanie L Bielas and Holden Richard Higginbotham and Hiroyuki Koizumi and Teruyuki Tanaka and Joseph G Gleeson},
  journal={Annual review of cell and developmental biology},
During brain development, neurons migrate great distances from proliferative zones to generate the cortical gray matter. A series of studies has identified genes that are critical for migration and targeting of neurons to specific brain regions. These genes encode three basic groups of proteins and produce three distinct phenotypes. The first group encodes cytoskeletal molecules and produces graded and dosage-dependent effects, with a significant amount of functional redundancy. This group also… CONTINUE READING


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[p27Kip1 independently promotes neuronal differentiation and migration in the cerebral cortex].

Bulletin et memoires de l'Academie royale de medecine de Belgique • 2006
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