Cortical morphometry in attention deficit/hyperactivity disorder: Contribution of thickness and surface area to volume

@article{Silk2016CorticalMI,
  title={Cortical morphometry in attention deficit/hyperactivity disorder: Contribution of thickness and surface area to volume},
  author={Timothy J. Silk and Richard Beare and Charles B. Malpas and Christopher L. Adamson and Veronika Vilgis and Alasdair Vance and Mark A. Bellgrove},
  journal={Cortex},
  year={2016},
  volume={82},
  pages={1-10}
}
Although lower brain volume is a consistent neuroimaging finding in attention deficit hyperactivity disorder (ADHD), we lack an understanding of whether this effect is driven by changes in cortical thickness or surface area, which are governed by distinct neurodevelopmental processes. This study examined ADHD-control differences in cortical thickness, surface area and volume, and tests whether thickness and surface area mediates any observed volume differences. Magnetic resonance imaging (MRI… Expand
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References

SHOWING 1-10 OF 43 REFERENCES
Widespread cortical thinning is a robust anatomical marker for attention-deficit/hyperactivity disorder.
  • K. Narr, R. Woods, +7 authors J. Levitt
  • Psychology, Medicine
  • Journal of the American Academy of Child and Adolescent Psychiatry
  • 2009
TLDR
Observations of widespread cortical thinning expand on earlier cross-sectional findings and provide further evidence to support that the neurobiological underpinnings of ADHD extend beyond prefrontal and subcortical circuits. Expand
Cortical Gray Matter in Attention-Deficit/Hyperactivity Disorder: A Structural Magnetic Resonance Imaging Study
  • M. Batty, E. Liddle, +7 authors C. Hollis
  • Psychology, Chemistry
  • Journal of the American Academy of Child and Adolescent Psychiatry
  • 2010
TLDR
The cortex of the pars opercularis was thinner in children with ADHD who, as expected, had significantly poorer inhibitory performance on a Go/No-go task, raising the possibility that a developmental abnormality of IFG might drive development of inhibition difficulties. Expand
Cortical thinning of the attention and executive function networks in adults with attention-deficit/hyperactivity disorder.
TLDR
This is the first documentation that ADHD in adults is associated with thinner cortex in the cortical networks that modulate attention and EF, and this network is located in the right hemisphere involving the inferior parietal lobule, the dorsolateral prefrontal, and the anterior cingulate cortices. Expand
Brain Cortical Thickness in ADHD
TLDR
The data support the hypothesis that anatomical abnormalities in ADHD represent abnormal development rather than developmental delay, and the CT differences were correlated with severity of ADHD. Expand
Global and regional gray matter reductions in ADHD: A voxel-based morphometric study
TLDR
The results are consistent with previous studies that used different techniques, and may represent a possible neural basis for some of the motor and attentional deficits commonly found in ADHD. Expand
Smaller prefrontal and premotor volumes in boys with attention-deficit/hyperactivity disorder
TLDR
Findings suggest that ADHD is associated with decreased frontal lobe gray and white matter volumes, suggesting that the clinical picture of ADHD encompasses dysfunctions attributable to anomalous development of both premotor and prefrontal cortices. Expand
Longitudinal mapping of cortical thickness and clinical outcome in children and adolescents with attention-deficit/hyperactivity disorder.
TLDR
Children with ADHD show relative cortical thinning in regions important for attentional control, and right parietal cortex thickness normalization in patients with a better outcome may represent compensatory cortical change. Expand
Development of Cortical Surface Area and Gyrification in Attention-Deficit/Hyperactivity Disorder
TLDR
The congruent delay in cortical thickness and surface area direct attention away from processes that selectively affect one cortical component toward mechanisms controlling the maturation of multiple cortical dimensions. Expand
Distinct genetic influences on cortical surface area and cortical thickness.
TLDR
It is demonstrated that cortical volume measures combine at least 2 distinct sources of genetic influences, and using volume in a genetically informative study, or as an endophenotype for a disorder, may confound the underlying genetic architecture of brain structure. Expand
Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation
TLDR
Maturation to progress in a similar manner regionally in both children with and without ADHD, with primary sensory areas attaining peak cortical thickness before polymodal, high-order association areas, and there was a marked delay in ADHD in attainingpeak thickness throughout most of the cerebrum. Expand
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5
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