Cortical morphometry in attention deficit/hyperactivity disorder: Contribution of thickness and surface area to volume

  title={Cortical morphometry in attention deficit/hyperactivity disorder: Contribution of thickness and surface area to volume},
  author={Timothy J. Silk and Richard Beare and Charles B. Malpas and Christopher L. Adamson and Veronika Vilgis and Alasdair Vance and Mark A. Bellgrove},

Structural and functional neuroimaging in attention‐deficit/hyperactivity disorder

Brain structure, magnetic resonance imaging, and diffusion tensor imaging studies have evidenced differences in volume, surface‐based measures, and white matter integrity in different cerebral regions, in children and adults with ADHD compared to population norms.

Cortical Thickness and Subcortical Volumes in Adolescent Synthetic Cannabinoid Users with or Without ADHD: a Preliminary Study.

The results suggest that similar to cannabis use, SC use has also negative effects on brain morphology and comorbidity of ADHD and substance dependence may show different cortical thickness and subcortical volume alterations than substance use alone.

Altered brain morphology in boys with attention deficit hyperactivity disorder with and without comorbid conduct disorder/oppositional defiant disorder

The necessity to carefully differentiate between ADHD and ADHD+ODD/CD is demonstrated, as patients with the double burden ADHD and ODD or CD seem to be even more affected than patients with pure ADHD.

Structural Brain Changes and Associated Symptoms of ADHD Subtypes in Children.

It is indicated that there are significant differences in clinical symptoms and gray matter damage between ADHD-Combined and -Inattentive patients, which supports the growing evidence of heterogeneity in the ADHD-InattENTive subtype and the evidence of brain structure differences.

Altered brain morphology in boys with attention-deficit/hyperactivity disorder with and without comorbid conduct disorder/oppositional defiant disorder

Overall, the structural profile of ADHD-only versus ADHD+ODD/CD spanning different indices is investigated, finding similarities but also differences in brain morphology between the two related disorders.

Exploring characteristic features of attention-deficit/hyperactivity disorder: findings from multi-modal MRI and candidate genetic data

Findings suggest that structural deformities relevant to salience detection, sensory processing, and response inhibition may be robust classifiers and symptom predictors of ADHD.

Surface values, volumetric measurements and radiomics of structural MRI for the diagnosis and subtyping of attention‐deficit/hyperactivity disorder

MRI T1‐weighted features, especially radiomic features, are potential diagnostic biomarkers of ADHD, and the radiomics‐based model outperformed the others in discriminating ADHD from TDC and classifying ADHD subtypes.



Widespread cortical thinning is a robust anatomical marker for attention-deficit/hyperactivity disorder.

  • K. NarrR. Woods J. Levitt
  • Psychology, Medicine
    Journal of the American Academy of Child and Adolescent Psychiatry
  • 2009
Observations of widespread cortical thinning expand on earlier cross-sectional findings and provide further evidence to support that the neurobiological underpinnings of ADHD extend beyond prefrontal and subcortical circuits.

Cortical Gray Matter in Attention-Deficit/Hyperactivity Disorder: A Structural Magnetic Resonance Imaging Study

  • M. BattyE. Liddle C. Hollis
  • Medicine, Psychology
    Journal of the American Academy of Child and Adolescent Psychiatry
  • 2010

Cortical thinning of the attention and executive function networks in adults with attention-deficit/hyperactivity disorder.

This is the first documentation that ADHD in adults is associated with thinner cortex in the cortical networks that modulate attention and EF, and this network is located in the right hemisphere involving the inferior parietal lobule, the dorsolateral prefrontal, and the anterior cingulate cortices.

Brain Cortical Thickness in ADHD

The data support the hypothesis that anatomical abnormalities in ADHD represent abnormal development rather than developmental delay, and the CT differences were correlated with severity of ADHD.

Longitudinal mapping of cortical thickness and clinical outcome in children and adolescents with attention-deficit/hyperactivity disorder.

Children with ADHD show relative cortical thinning in regions important for attentional control, and right parietal cortex thickness normalization in patients with a better outcome may represent compensatory cortical change.

Distinct genetic influences on cortical surface area and cortical thickness.

It is demonstrated that cortical volume measures combine at least 2 distinct sources of genetic influences, and using volume in a genetically informative study, or as an endophenotype for a disorder, may confound the underlying genetic architecture of brain structure.

Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation

Maturation to progress in a similar manner regionally in both children with and without ADHD, with primary sensory areas attaining peak cortical thickness before polymodal, high-order association areas, and there was a marked delay in ADHD in attainingpeak thickness throughout most of the cerebrum.