Cortical microarchitecture changes in genetic epilepsy.

OBJECTIVE The human GABAAγ2(R43Q) mutation is associated with genetic epilepsy. Because of the role of γ-aminobutyric acid (GABA) in brain development, we asked whether this epilepsy mutation might affect excitability by changing cortical cytoarchitecture. METHODS We used a mouse model harboring a heterozygous R43Q missense mutation in the GABAA receptor… CONTINUE READING