Cortical map reorganization enabled by nucleus basalis activity.

@article{Kilgard1998CorticalMR,
  title={Cortical map reorganization enabled by nucleus basalis activity.},
  author={Michael P. Kilgard and Michael Merzenich},
  journal={Science},
  year={1998},
  volume={279 5357},
  pages={
          1714-8
        }
}
  • Michael P. Kilgard, Michael Merzenich
  • Published in Science 1998
  • Biology, Medicine
  • Little is known about the mechanisms that allow the cortex to selectively improve the neural representations of behaviorally important stimuli while ignoring irrelevant stimuli. Diffuse neuromodulatory systems may facilitate cortical plasticity by acting as teachers to mark important stimuli. This study demonstrates that episodic electrical stimulation of the nucleus basalis, paired with an auditory stimulus, results in a massive progressive reorganization of the primary auditory cortex in the… CONTINUE READING

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    Supported by NIH grant NS-10414, Hearing Research Inc., and an NSF predoctoral fellowship. We thank C. Schreiner for technical advice and Miller for helpful comments on the manuscript

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