Cortical involvement in Marchiafava-Bignami disease.

  title={Cortical involvement in Marchiafava-Bignami disease.},
  author={Ken Johkura and Makoto Naito and Takayuki Naka},
  journal={AJNR. American journal of neuroradiology},
  volume={26 3},
Marchiafava-Bignami disease (MBD), a rare complication of chronic alcoholism, is characterized by primary demyelination of the corpus callosum. We report two cases of MBD in which fluid-attenuated inversion recovery (FLAIR) and diffusion-weighted imaging studies revealed symmetrical hyperintense lesions in the cerebral cortex (particularly in the lateral-frontal regions) in addition to the callosal lesions, which suggests an association of diffuse cortical lesions such as Morel's laminar… CONTINUE READING


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