Cortical interneurons, immune factors and oxidative stress as early targets for schizophrenia.

@article{ODonnell2012CorticalII,
  title={Cortical interneurons, immune factors and oxidative stress as early targets for schizophrenia.},
  author={Patricio O'Donnell},
  journal={The European journal of neuroscience},
  year={2012},
  volume={35 12},
  pages={1866-70}
}
Schizophrenia is a common disorder in which strong genetic predisposition is combined with environmental factors. Despite the widely recognized developmental nature of the disease, symptoms do not emerge until late adolescence. Current therapeutic approaches are therefore employed too late, as brain alterations may have been present earlier than symptom onset. Here I review the developmental trajectory of the cortical circuits responsible for excitation-inhibition balance, which are at the… CONTINUE READING