Cortical inhibitory neurons and schizophrenia

@article{Lewis2005CorticalIN,
  title={Cortical inhibitory neurons and schizophrenia},
  author={David A. Lewis and Takanori Hashimoto and David W. Volk},
  journal={Nature Reviews Neuroscience},
  year={2005},
  volume={6},
  pages={312-324}
}
Impairments in certain cognitive functions, such as working memory, are core features of schizophrenia. Convergent findings indicate that a deficiency in signalling through the TrkB neurotrophin receptor leads to reduced GABA (γ-aminobutyric acid) synthesis in the parvalbumin-containing subpopulation of inhibitory GABA neurons in the dorsolateral prefrontal cortex of individuals with schizophrenia. Despite both pre- and postsynaptic compensatory responses, the resulting alteration in… CONTINUE READING
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