Cortical inhibitory neurons and schizophrenia

@article{Lewis2005CorticalIN,
  title={Cortical inhibitory neurons and schizophrenia},
  author={D. Lewis and T. Hashimoto and D. Volk},
  journal={Nature Reviews Neuroscience},
  year={2005},
  volume={6},
  pages={312-324}
}
  • D. Lewis, T. Hashimoto, D. Volk
  • Published 2005
  • Medicine, Biology
  • Nature Reviews Neuroscience
  • Impairments in certain cognitive functions, such as working memory, are core features of schizophrenia. Convergent findings indicate that a deficiency in signalling through the TrkB neurotrophin receptor leads to reduced GABA (γ-aminobutyric acid) synthesis in the parvalbumin-containing subpopulation of inhibitory GABA neurons in the dorsolateral prefrontal cortex of individuals with schizophrenia. Despite both pre- and postsynaptic compensatory responses, the resulting alteration in… CONTINUE READING

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    Caffeine is the most used psychoactive drug in Canada, with regular consumption by 88% of the adult population, While rates of caffeine consumption are considered to be high in the… Expand
    ConditionsCaffeine, Schizophrenia
    InterventionDrug
    INTERVENTIONAL CLINICAL TRIAL
    Patients with schizophrenia are characterized by a broad range of neurocognitive abnormalities. These include impairments in attention, including abnormalities in sensory gating… Expand
    ConditionsSchizophrenia
    InterventionDrug
    INTERVENTIONAL CLINICAL TRIAL
    The purpose of this research study is to determine whether a short-term administration of an investigational study drug may provide evidence of improvement in cognitive functioning in a… Expand
    ConditionsSchizophrenia
    InterventionDrug
    Cognitive Dysfunction in Schizophrenia
    8
    Perisomatic inhibition and cortical circuit dysfunction in schizophrenia
    79
    Prefrontal cortical circuits in schizophrenia.
    98
    Neuroplasticity of excitatory and inhibitory cortical circuits in schizophrenia
    44
    Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia
    241
    Neuroplasticity of Neocortical Circuits in Schizophrenia
    321

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 157 REFERENCES