Cortical hypometabolism and hypoperfusion in Parkinson’s disease is extensive: probably even at early disease stages

@article{Borghammer2010CorticalHA,
  title={Cortical hypometabolism and hypoperfusion in Parkinson’s disease is extensive: probably even at early disease stages},
  author={Per Borghammer and M. Mallar Chakravarty and Kristjana Yr Jonsdottir and Noriko Sato and Hiroshi Matsuda and Kengo Ito and Yutaka Arahata and Takashi Kato and Albert Gjedde},
  journal={Brain Structure and Function},
  year={2010},
  volume={214},
  pages={303-317}
}
Recent cerebral blood flow (CBF) and glucose consumption (CMRglc) studies of Parkinson’s disease (PD) revealed conflicting results. Using simulated data, we previously demonstrated that the often-reported subcortical hypermetabolism in PD could be explained as an artifact of biased global mean (GM) normalization, and that low-magnitude, extensive cortical hypometabolism is best detected by alternative data-driven normalization methods. Thus, we hypothesized that PD is characterized by extensive… CONTINUE READING

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