Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis.

Abstract

Familial amyotrophic lateral sclerosis (FALS) is an inherited neurodegenerative disorder of the motor neurons. While 10-15% of cases are caused by mutations in the copper/zinc superoxide-dismutase-1 (SOD-1) gene, the dying-forward hypothesis, in which corticomotoneurons induce anterograde excitotoxic motoneuron degeneration, has been proposed as a potential… (More)
DOI: 10.1093/brain/awn071

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