Cortical folding scales universally with surface area and thickness, not number of neurons

@article{Mota2015CorticalFS,
  title={Cortical folding scales universally with surface area and thickness, not number of neurons},
  author={Bruno Mota and Suzana Herculano-Houzel},
  journal={Science},
  year={2015},
  volume={349},
  pages={74-77}
}
Larger brains tend to have more folded cortices, but what makes the cortex fold has remained unknown. We show that the degree of cortical folding scales uniformly across lissencephalic and gyrencephalic species, across individuals, and within individual cortices as a function of the product of cortical surface area and the square root of cortical thickness. This relation is derived from the minimization of the effective free energy associated with cortical shape according to a simple physical… CONTINUE READING

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