Cortical folding in patients with bipolar disorder or unipolar depression.

  title={Cortical folding in patients with bipolar disorder or unipolar depression.},
  author={Jani Penttil{\"a} and Marie-Laure Paill{\`e}re-Martinot and Jean-Luc Martinot and Damien Ringuenet and Mich{\`e}le Wessa and Josselin Houenou and Thierry Gallarda and Frank Bellivier and Andr{\'e} Galinowski and Pascale Brugui{\`e}re and François Pinabel and Marion Leboyer and J. J. Olie and Edouard Duchesnay and Eric Artiges and Jean-Francois Mangin and Arnaud Cachia},
  journal={Journal of psychiatry & neuroscience : JPN},
  volume={34 2},
BACKGROUND Analysis of cortical folding may provide insight into neurodevelopment deviations, which, in turn, can predispose to depression that responds particularly poorly to medications. We hypothesized that patients with treatment-resistant depression would exhibit measurable alterations in cortical folding. METHODS We computed hemispheric global sulcal indices (g-SIs) in T(1)-weighted magnetic resonance images obtained from 76 patients and 70 healthy controls. We separately searched for… CONTINUE READING