Cortical folding defects as markers of poor treatment response in first-episode psychosis.

  title={Cortical folding defects as markers of poor treatment response in first-episode psychosis.},
  author={Lena Palaniyappan and Tiago Reis Marques and Heather Taylor and Rowena Handley and Valeria Mondelli and Stefania Bonaccorso and Annalisa Giordano and Grant McQueen and Marta Diforti and Andrew Simmons and Anthony S. David and Carmine M Pariante and Robin MacGregor Murray and Paola Dazzan},
  journal={JAMA psychiatry},
  volume={70 10},
IMPORTANCE At present, no reliable predictors exist to distinguish future responders from nonresponders to treatment during the first episode of psychosis. Among potential neuroimaging predictors of treatment response, gyrification represents an important marker of the integrity of normal cortical development that may characterize, already at illness onset, a subgroup of patients with particularly poor outcome. OBJECTIVE To determine whether patients with first-episode psychosis who do not… CONTINUE READING

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