Cortical excitability in amyotrophic lateral sclerosis: a clue to pathogenesis.

  title={Cortical excitability in amyotrophic lateral sclerosis: a clue to pathogenesis.},
  author={A. Eisen and B. Pant and Heather L Stewart},
  journal={The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques},
  volume={20 1},
Motor evoked potentials (MEPs) were recorded from selected non-wasted, non-denervated hand muscles in 40 patients with Amyotrophic Lateral Sclerosis (ALS) with both upper and lower motor neuron signs. In most the compound muscle action potential (CMAP) of the target muscle was normal. Compared to the control group, cortical threshold in ALS varied considerably and there was a significant (r2 = 0.702) inverse, exponential, correlation between cortical threshold and MEP/CMAP ratio. There was a… CONTINUE READING
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