Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members.

@article{Herms2004CorticalDR,
  title={Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members.},
  author={Jochen Herms and Brigitte Anliker and Sabine Heber and Sabine Ring and Martin Fuhrmann and Hans Kretzschmar and Sangram S. Sisodia and Ulrike M{\"u}ller},
  journal={The EMBO journal},
  year={2004},
  volume={23 20},
  pages={4106-15}
}
The Alzheimer's disease beta-amyloid precursor protein (APP) is a member of a larger gene family that includes the amyloid precursor-like proteins, termed APLP1 and APLP2. We previously documented that APLP2-/-APLP1-/- and APLP2-/-APP-/- mice die postnatally, while APLP1-/-APP-/- mice and single mutants were viable. We now report that mice lacking all three APP/APLP family members survive through embryonic development, and die shortly after birth. In contrast to double-mutant animals with… CONTINUE READING