Cortical dopamine dysfunction in symptomatic and premanifest Huntington's disease gene carriers.

@article{Pavese2010CorticalDD,
  title={Cortical dopamine dysfunction in symptomatic and premanifest Huntington's disease gene carriers.},
  author={Nicola Pavese and Marios Politis and Yen Tai and Roger A. Barker and Sarah J Tabrizi and S L Mason and David J. Brooks and Paola Piccini},
  journal={Neurobiology of disease},
  year={2010},
  volume={37 2},
  pages={356-61}
}
We used (11)C-raclopride PET, a marker of D(2) dopamine receptor binding, and statistical parametric mapping (SPM) to localise cortical D(2) receptor dysfunction in individual Huntington's disease (HD) gene carriers (16 symptomatic and 11 premanifest subjects) and assess its clinical significance. 62.5% of symptomatic HD patients and 54.5% of premanifest carriers showed cortical reductions in D(2) binding. The most frequent decreases in cortical binding in individual HD subjects were seen in… CONTINUE READING
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