Cortical demyelination and diffuse white matter injury in multiple sclerosis.

@article{Kutzelnigg2005CorticalDA,
  title={Cortical demyelination and diffuse white matter injury in multiple sclerosis.},
  author={A. Kutzelnigg and C. Lucchinetti and C. Stadelmann and W. Br{\"u}ck and H. Rauschka and M. Bergmann and M. Schmidbauer and J. Parisi and H. Lassmann},
  journal={Brain : a journal of neurology},
  year={2005},
  volume={128 Pt 11},
  pages={
          2705-12
        }
}
Focal demyelinated plaques in white matter, which are the hallmark of multiple sclerosis pathology, only partially explain the patient's clinical deficits. We thus analysed global brain pathology in multiple sclerosis, focusing on the normal-appearing white matter (NAWM) and the cortex. Autopsy tissue from 52 multiple sclerosis patients (acute, relapsing-remitting, primary and secondary progressive multiple sclerosis) and from 30 controls was analysed using quantitative morphological techniques… Expand
Cortical pathology in multiple sclerosis
Meningeal and cortical grey matter pathology in multiple sclerosis
Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron
Inflammatory cortical demyelination in early multiple sclerosis.
Grey matter pathology in multiple sclerosis
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 59 REFERENCES
Axonal transection in the lesions of multiple sclerosis.
Axonal changes in chronic demyelinated cervical spinal cord plaques.
Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions
  • John W. Peterson, Lars Bö, Sverre Mörk, A. Chang, B. Trapp
  • Biology, Medicine
  • Annals of neurology
  • 2001
Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis.
Diffuse axonal and tissue injury in patients with multiple sclerosis with low cerebral lesion load and no disability.
Immunopathology of secondary‐progressive multiple sclerosis
In vivo assessment of the brain and cervical cord pathology of patients with primary progressive multiple sclerosis.
...
1
2
3
4
5
...