Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments.

@article{Guizetti2011CorticalCD,
  title={Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments.},
  author={Julien Guizetti and Lothar Schermelleh and Jana M{\"a}ntler and Sandra Maar and Ina Poser and Heinrich Leonhardt and Thomas M{\"u}ller-Reichert and Daniel W Gerlich},
  journal={Science},
  year={2011},
  volume={331 6024},
  pages={1616-20}
}
After partitioning of cytoplasmic contents by cleavage furrow ingression, animal cells remain connected by an intercellular bridge, which subsequently splits by abscission. Here, we examined intermediate stages of abscission in human cells by using live imaging, three-dimensional structured illumination microscopy, and electron tomography. We identified helices of 17-nanometer-diameter filaments, which narrowed the cortex of the intercellular bridge to a single stalk. The endosomal sorting… CONTINUE READING
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