Cortical cholinergic function and deficits in visual attentional performance in rats following 192 IgG-saporin-induced lesions of the medial prefrontal cortex.

@article{Dalley2004CorticalCF,
  title={Cortical cholinergic function and deficits in visual attentional performance in rats following 192 IgG-saporin-induced lesions of the medial prefrontal cortex.},
  author={Jeffrey W. Dalley and David E. H. Theobald and Pascale C M Bouger and Yogita Chudasama and Rudolf N. Cardinal and Trevor W. Robbins},
  journal={Cerebral cortex},
  year={2004},
  volume={14 8},
  pages={922-32}
}
Lesions of the basal forebrain (BF) cortical cholinergic system impair performance on a rodent five-choice visual attentional task. This study examines the effects on the same task of selective depletion of acetylcholine from the prefrontal cortex (PFC) using 192 IgG-saporin, the cholinergic immunotoxin. Rats were trained to detect brief visual stimuli… CONTINUE READING