Cortical changes in cholecystokinin mRNA are related to spontaneous pain behaviors following excitotoxic spinal cord injury in the rat.

@article{Brewer2003CorticalCI,
  title={Cortical changes in cholecystokinin mRNA are related to spontaneous pain behaviors following excitotoxic spinal cord injury in the rat.},
  author={Kori L. Brewer and David McMillan and Todd A. Nolan and Kerry Shum},
  journal={Brain research. Molecular brain research},
  year={2003},
  volume={118 1-2},
  pages={
          171-4
        }
}
Cholecystokinin (CCK) in the CNS antagonizes the opioid system and has been implicated post-spinal cord injury (SCI) pain. The current study found that excitotoxic SCI alters levels of CCK mRNA levels in the cortex, diencepahlon, and mesencephalon of rats. Animals that developed pain post-SCI had significantly higher levels than animals that did not develop pain. Upregulation of CCK mRNA in the cortex may be related to post-SCI pain in rats. 

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