Cortical blood flow assessment with frequency-domain laser Doppler microscopy.

@article{Atlan2007CorticalBF,
  title={Cortical blood flow assessment with frequency-domain laser Doppler microscopy.},
  author={Michael Atlan and Ben{\^i}ot C Forget and A. Claude Boccara and Tania Vitalis and Armelle Rancillac and Andrew K. Dunn and Michel Gross},
  journal={Journal of biomedical optics},
  year={2007},
  volume={12 2},
  pages={024019}
}
We report the assessment of cerebral blood flow (CBF) changes with a wide-field laser Doppler imager based on a CCD camera detection scheme, in vivo, in mice. The setup enables the acquisition of data in minimally invasive conditions. In contrast with conventional laser Doppler velocimeters and imagers, the Doppler signature of moving scatterers is measured in the frequency domain, by detuning a heterodyne optical detection. The quadratic mean of the measured frequency shift is used as an… CONTINUE READING