Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Intraventricular Bethanecol Study Group.

@article{DeKosky1992CorticalBI,
  title={Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Intraventricular Bethanecol Study Group.},
  author={S. T. DeKosky and Robert E. Harbaugh and Frederick A. Schmitt and R. Bakay and Helena Chang Chui and David S. Knopman and Thomas M. Reeder and Andrew G. Shetter and H J Senter and William R. Markesbery},
  journal={Annals of neurology},
  year={1992},
  volume={32 5},
  pages={625-32}
}
Neurochemical assessments were performed on biopsy samples taken from the right frontal lobe of patients diagnosed with Alzheimer's disease (AD), before the implantation of a ventricular catheter and pump assembly for the infusion of bethanechol chloride as an experimental therapy. The pathologically diagnosed patients with AD (n = 35; mean age, 67 +/- 1.5 yr) were compared with a group of samples from normal age-equivalent autopsied controls (n = 22; mean age, 68 +/- 2 yr) and autopsied AD… CONTINUE READING