Cortical atrophy in ALS is critically associated with neuropsychiatric and cognitive changes.

@article{Mioshi2013CorticalAI,
  title={Cortical atrophy in ALS is critically associated with neuropsychiatric and cognitive changes.},
  author={Eneida Mioshi and Patricia Lillo and Belinda Yew and Sharpley Hsieh and Sharon A Savage and John R. Hodges and Matthew C Kiernan and Michael Hornberger},
  journal={Neurology},
  year={2013},
  volume={80 12},
  pages={1117-23}
}
OBJECTIVE To characterize the patterns of brain atrophy in patients with amyotrophic lateral sclerosis (ALS) with and without cognitive and neuropsychiatric symptoms, in comparison to controls and patients with ALS-frontotemporal dementia (FTD). METHODS A total of 57 participants (ALS = 22; ALS-FTD = 17; controls = 18) were included, following current ALS and FTD criteria. Patients with ALS were further subclassified into ALS with cognitive and behavioral symptoms (ALS-plus; n = 8) and those… CONTINUE READING
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