Cortical atrophy and hypoperfusion in a transgenic mouse model of Alzheimer's disease.

  title={Cortical atrophy and hypoperfusion in a transgenic mouse model of Alzheimer's disease.},
  author={Francois Olivier Hebert and Marilyn Grand'maison and Ming-Kai Ho and Jason P. Lerch and Edith Hamel and Barry J. Bedell},
  journal={Neurobiology of aging},
  volume={34 6},
Magnetic resonance imaging studies have revealed distinct patterns of cortical atrophy and hypoperfusion in patients with Alzheimer's disease. The relationship between these in vivo imaging measures and the corresponding underlying pathophysiological changes, however, remains elusive. Recently, attention has turned to neuroimaging of mouse models of Alzheimer's disease in which imaging-pathological correlations can be readily performed. In this study, anatomical and arterial spin labeling… CONTINUE READING
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