Cortical and subcortical generators of normal and abnormal rhythmicity.

  title={Cortical and subcortical generators of normal and abnormal rhythmicity.},
  author={David A. McCormick},
  journal={International review of neurobiology},
The cerebral cortex and thalamus can both generate cyclical oscillations of neuronal activity. Within the thalamus, sleep spindles are generated as a recurrent interaction between thalamocortical and thalamic reticular cells. Abnormally strong activation of the inhibitory thalamic reticular neurons can result in the transformation of this normal rhythm into one that resembles that underlying absence seizures. The cerebral cortex can generate periodic activity at < 1 Hz through recurrent… CONTINUE READING
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