Cortical Thickness and Microstructural White Matter Changes Detect Amnestic Mild Cognitive Impairment.

@article{Wang2017CorticalTA,
  title={Cortical Thickness and Microstructural White Matter Changes Detect Amnestic Mild Cognitive Impairment.},
  author={Zan Wang and Zhengjia Dai and Hao Shu and Duan Liu and Qihao Guo and Yong He and Zhi-Jun Zhang},
  journal={Journal of Alzheimer's disease : JAD},
  year={2017},
  volume={56 1},
  pages={
          415-428
        }
}
Both the apolipoprotein E (APOE) ɛ4 allele and amnestic mild cognitive impairment (aMCI) are considered to be risk factors for Alzheimer's disease (AD). The primary aim of this study was to determine whether the aMCI-related abnormality in gray matter (GM) cortical thickness and white matter (WM) tracts integrity would be modified by the APOE genotype. A total of 146 older adults, including 64 aMCI patients (28 ɛ4 carriers and 36 non-carriers) and 82 healthy controls (39 ɛ4 carriers and 43 non… CONTINUE READING