Cortical Synaptic Transmission and Plasticity in Acute Liver Failure Are Decreased by Presynaptic Events

@inproceedings{Popek2016CorticalST,
  title={Cortical Synaptic Transmission and Plasticity in Acute Liver Failure Are Decreased by Presynaptic Events},
  author={Mariusz Popek and Bartosz Bobula and Joanna Sowa and Grzegorz Hess and Rafał Polowy and Robert Kuba Filipkowski and Małgorzata Frontczak-Baniewicz and Barbara Zabłocka and Jan Albrecht and Magdalena Zielińska},
  booktitle={Molecular Neurobiology},
  year={2016}
}
Neurological symptoms of acute liver failure (ALF) reflect decreased excitatory transmission, but the status of ALF-affected excitatory synapse has not been characterized in detail. We studied the effects of ALF in mouse on synaptic transmission and plasticity ex vivo and its relation to distribution of (i) synaptic vesicles (sv) and (ii) functional synaptic proteins within the synapse. ALF-competent neurological and biochemical changes were induced in mice with azoxymethane (AOM… CONTINUE READING

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