Cortical Structural Connectivity Alterations and Potential Pathogenesis in Mid-Stage Sporadic Parkinson’s Disease

  title={Cortical Structural Connectivity Alterations and Potential Pathogenesis in Mid-Stage Sporadic Parkinson’s Disease},
  author={Xia Deng and Zheng Liu and Qin Kang and Lin Lu and Yu Zhu and Renshi Xu},
  journal={Frontiers in Aging Neuroscience},
Many clinical symptoms of sporadic Parkinson’s disease (sPD) cannot be completely explained by a lesion of the simple typical extrapyramidal circuit between the striatum and substantia nigra. Therefore, this study aimed to explore the new potential damaged pathogenesis of other brain regions associated with the multiple and complex clinical symptoms of sPD through magnetic resonance imaging (MRI). A total of 65 patients with mid-stage sPD and 35 healthy controls were recruited in this study… 

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