Cortical PIB binding in Lewy body disease is associated with Alzheimer-like characteristics

  title={Cortical PIB binding in Lewy body disease is associated with Alzheimer-like characteristics},
  author={Walter Maetzler and Inga Liepelt and Matthias Reimold and Gerald Reischl and D. Berg},
  journal={Neurobiology of Disease},
About one fourth of Lewy body disease (LBD) patients show cortical beta-amyloid load, basically a hallmark of Alzheimer disease (AD). Using [11C]PIB-PET, we tested whether LBD patients with beta-amyloid burden differ from those without with respect to demographic, clinical, biochemical and genetic parameters. Thirty-five LBD subjects (9 patients with Lewy body dementia, DLB; 12 demented Parkinson patients, PDD; 14 non-demented PD, PDND) underwent [11C]PIB-PET, and were classified as either PIB… CONTINUE READING
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