Cortical Information Processing in Coma

@article{Daltrozzo2009CorticalIP,
  title={Cortical Information Processing in Coma},
  author={J{\'e}r{\^o}me Daltrozzo and Norma Wioland and V{\'e}ronique Mutschler and Philippe Lutun and Bartholomeus Calon and Alaina Meyer and Thierry Pottecher and Simone Lang and Albert Jaeger and Boris Kotchoubey},
  journal={Cognitive and Behavioral Neurology},
  year={2009},
  volume={22},
  pages={53-62}
}
ObjectivesTo evaluate cortical information processing (particularly, semantic processing) in acute nontraumatic coma by means of event-related brain potentials (ERPs). MethodsThe tests included measures of obligatory auditory processing (N100), automatic (Mismatch Negativity) and controlled (P300) detection of stimulus deviance, and semantic processing (ERP effects in word pairs and sentences). The tests were presented to 20 healthy participants and 42 coma patients with Glasgow Coma Scale <9… 
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35 Citations
Highly Influential Citations
4
Background Citations
14
Methods Citations
7
Results Citations
3

35 Citations

Semantic processing in comatose patients with intact temporal lobes as reflected by the N400 event-related potential

Cognitive auditory evoked potentials in coma: can you hear me?

This scientific commentary refers to ‘Neural detection of complex sound sequences in the absence of consciousness’, by Tzovara et al. (doi:10.1093/brain/awv041) as well as event related potentials, which are the electrophysiological brain responses to a stimulus.

Prognostic Use of Cognitive Event-Related Potentials in Acute Consciousness Impairment

Here, a general framework for assessing the degree of auditory discrimination over time is proposed, as a process that degenerates in non-survivors and that improves in patients who eventually awake.

Information processing in patients in vegetative and minimally conscious states

The N400 for brain computer interfacing: complexities and opportunities

It is illustrated that the N400 can successfully be exploited for BCI purposes, but that the signal-to-noise ratio is a limiting factor, with signal strength also varying strongly across subjects.

A rapid event-related potential (ERP) method for point-of-care evaluation of brain function: Development of the Halifax Consciousness Scanner

Single-subject analysis of N400 event-related potential component with five different methods.

Replicability and impact of statistics in the detection of neural responses of consciousness.

This discussion raises important questions on the way to use event-related potentials (ERPs) for predicting the recovery of comatose patients and the difficulty in obtaining a perfect neural detection in the control group of fully conscious subjects and the variability of the statistical analyses used to detect neural signs of awareness.

PRESERVED NEURAL FUNCTIONS IN POST-ANOXIC COMA AND THEIR ADDED VALUE FOR THE PREDICTION OF COGNITIVE AND FUNCTIONAL OUTCOME

The results suggest that the comatose brain can process a large variety of stimuli, shedding new light into the cerebral functions in this clinical state, and that its signal may provide reliable and detailed prognostic information.

Progression of auditory discrimination based on neural decoding predicts awakening from coma.

Electroencephalography responses based on a multivariate decoding algorithm that automatically quantifies neural discrimination at the single patient level show evidence of intact auditory processing even in comatose patients who do not survive and that progression of sound discrimination over time is informative of a patient's chance of survival.

References

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