Cortical Evolution: Judge the Brain by Its Cover

  title={Cortical Evolution: Judge the Brain by Its Cover},
  author={Daniel H. Geschwind and Pasko Raki{\'c}},
To understand the emergence of human higher cognition, we must understand its biological substrate--the cerebral cortex, which considers itself the crowning achievement of evolution. Here, we describe how advances in developmental neurobiology, coupled with those in genetics, including adaptive protein evolution via gene duplications and the emergence of novel regulatory elements, can provide insights into the evolutionary mechanisms culminating in the human cerebrum. Given that the massive… CONTINUE READING
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