Cortical/subcortical disease burden and cognitive impairment in patients with multiple sclerosis.

  title={Cortical/subcortical disease burden and cognitive impairment in patients with multiple sclerosis.},
  author={Marco Rovaris and Massimo Filippi and Laura Minicucci and Giuseppe Iannucci and Giuseppe Santuccio and Francesca Possa and Giancarlo Comi},
  journal={AJNR. American journal of neuroradiology},
  volume={21 2},
BACKGROUND AND PURPOSE We assessed whether the extent of macro- and microscopic disease in the cortical and subcortical brain tissue, as revealed by MR and magnetization transfer (MT) imaging, correlates with cognitive dysfunction in patients with multiple sclerosis (MS). METHODS Dual-echo rapid acquisition with relaxation enhancement (RARE), fast fluid-attenuated inversion recovery (fast-FLAIR), T1-weighted, and MT MR images of the brain were obtained from 16 MS patients with cognitive… CONTINUE READING


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