Cortactin regulates cell migration through activation of N-WASP.

@article{Kowalski2005CortactinRC,
  title={Cortactin regulates cell migration through activation of N-WASP.},
  author={Jennifer R. Kowalski and Coumaran Egile and Sonsoles Gonz{\'a}lez Gil and Scott B. Snapper and Rong Li and Sheila M. Thomas},
  journal={Journal of cell science},
  year={2005},
  volume={118 Pt 1},
  pages={
          79-87
        }
}
Cortactin is an actin-associated scaffolding protein that regulates cell migration. Amplification of the human gene, EMS1, has been detected in breast, head and neck tumors, where it correlates with increased invasiveness. Cortactin can regulate actin dynamics directly via its N-terminal half, which can bind and activate the Arp2/3 complex. The C-terminal portion of cortactin, however, is thought to have limited function in its regulation of the actin polymerization machinery. In this report… CONTINUE READING

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