Cortactin regulates cell migration through activation of N-WASP

  title={Cortactin regulates cell migration through activation of N-WASP},
  author={J. Kowalski and C. Egile and Susana Gil and S. Snapper and R. Li and S. Thomas},
  journal={Journal of Cell Science},
  pages={79 - 87}
  • J. Kowalski, C. Egile, +3 authors S. Thomas
  • Published 2005
  • Medicine, Biology
  • Journal of Cell Science
  • Cortactin is an actin-associated scaffolding protein that regulates cell migration. Amplification of the human gene, EMS1, has been detected in breast, head and neck tumors, where it correlates with increased invasiveness. Cortactin can regulate actin dynamics directly via its N-terminal half, which can bind and activate the Arp2/3 complex. The C-terminal portion of cortactin, however, is thought to have limited function in its regulation of the actin polymerization machinery. In this report… CONTINUE READING

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