Cortactin regulates cell migration through activation of N-WASP.


Cortactin is an actin-associated scaffolding protein that regulates cell migration. Amplification of the human gene, EMS1, has been detected in breast, head and neck tumors, where it correlates with increased invasiveness. Cortactin can regulate actin dynamics directly via its N-terminal half, which can bind and activate the Arp2/3 complex. The C-terminal… (More)


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@article{Kowalski2005CortactinRC, title={Cortactin regulates cell migration through activation of N-WASP.}, author={Jennifer R Kowalski and Coumaran Egile and Susana M Gil and Scott B. Snapper and Rong Li and Sheila M. Thomas}, journal={Journal of cell science}, year={2005}, volume={118 Pt 1}, pages={79-87} }