Cortactin associates with the cell-cell junction protein ZO-1 in both Drosophila and mouse.

@article{Katsube1998CortactinAW,
  title={Cortactin associates with the cell-cell junction protein ZO-1 in both Drosophila and mouse.},
  author={Takanori Katsube and Manabu Takahisa and Ryu Ueda and Noriyoshi Hashimoto and Masahiko Kobayashi and Shin Togashi},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 45},
  pages={29672-7}
}
Cortactin is an actin filament-binding protein localizing at cortical regions of cells and a prominent substrate for Src family protein-tyrosine kinases in response to multiple extracellular stimuli. Human cortactin has been identified as a protein product of a putative oncogene, EMS1. In this report, we describe the identification of a Drosophila homolog of cortactin as a molecule that interacts with Drosophila ZO-1 using yeast two-hybrid screening. Drosophila cortactin is a 559-amino acid… CONTINUE READING
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