Cortactin: Coordinating adhesion and the actin cytoskeleton at cellular protrusions.

@article{Ren2009CortactinCA,
  title={Cortactin: Coordinating adhesion and the actin cytoskeleton at cellular protrusions.},
  author={Gang Ren and Matthew S. Crampton and Alpha S. Yap},
  journal={Cell motility and the cytoskeleton},
  year={2009},
  volume={66 10},
  pages={865-73}
}
It has long been recognized that adhesion receptors cooperate with the cytoskeleton during morphogenesis, tissue remodeling and homeostasis. But how this occurs is less well-understood. A host of cytoskeletal regulators have been reported to have functional and biochemical linkage with adhesion receptors. The challenge remains to find functionally-coherent patterns within this increasingly large corpus of molecular information. In this review we discuss one approach, to identify distinctive… CONTINUE READING

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