Corrigendum: Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs

@article{Khan2009CorrigendumTO,
  title={Corrigendum: Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs},
  author={Aly A. Khan and Doron Betel and Martin L. Miller and Chris Sander and Christina S. Leslie and Debora S. Marks},
  journal={Nature Biotechnology},
  year={2009},
  volume={27},
  pages={549-555}
}
Transfection of small RNAs (such as small interfering RNAs (siRNAs) and microRNAs (miRNAs)) into cells typically lowers expression of many genes. Unexpectedly, increased expression of genes also occurs. We investigated whether this upregulation results from a saturation effect—that is, competition among the transfected small RNAs and the endogenous pool of miRNAs for the intracellular machinery that processes small RNAs. To test this hypothesis, we analyzed genome-wide transcript responses from… CONTINUE READING