Corrigendum: Trading off stability against activity in extremophilic aldolases

  title={Corrigendum: Trading off stability against activity in extremophilic aldolases},
  author={Markus Dick and Oliver H. Weiergr{\"a}ber and Thomas Classen and Carolin Bisterfeld and Julia Bramski and Holger Gohlke and J{\"o}rg Pietruszka},
Understanding enzyme stability and activity in extremophilic organisms is of great biotechnological interest, but many questions are still unsolved. Using 2-deoxy-d-ribose-5-phosphate aldolase (DERA) as model enzyme, we have evaluated structural and functional characteristics of different orthologs from psychrophilic, mesophilic and hyperthermophilic organisms. We present the first crystal structures of psychrophilic DERAs, revealing a dimeric organization resembling their mesophilic but not… CONTINUE READING

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